Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefotaxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.98 |
| ▸ | MAPT | P10636 | 3/20 | 0.98 |
| ▸ | PPARG | P37231 | 2/20 | 0.98 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.98 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.98 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.98 |
| ▸ | ALB | P02768 | 1/20 | 0.98 |
| ▸ | HTR2C | P28335 | 1/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.85 |
| ▸ | APEX1 | P27695 | 3/20 | 0.85 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.85 |
| ▸ | LMNA | P02545 | 2/20 | 0.85 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.85 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.85 |
| ▸ | PKM | P14618 | 1/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.85 |
| ▸ | POLB | P06746 | 1/20 | 0.85 |
| ▸ | RECQL | P46063 | 1/20 | 0.85 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefotaxime SCHEMBL9342532 | 1.00 | NR1I2 (0.98) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL6017904 | 1.00 | NR1I2 (0.98) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL28159824 | 1.00 | NR1I2 (0.98) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL2220120 | 0.99 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL9395572 | 0.99 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL10748430 | 0.99 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL15410 | 0.99 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL14594281 | 0.99 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL3731937 | 0.99 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 | |
| Cefotaxime SCHEMBL17422140 | 0.99 | NR1I2 (1.00) | NR1I2MAPTPPARGSLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108558908-B | A kind of desalination method of ceftazidime mother liquor and the preparation method of cefotaxime | 华北制药河北华民药业有限责任公司 | 2019-11-29 | — | — | CN | claimed |
| CN-109912625-A | A kind of process reducing cefotaxime impurity H | 辽宁美亚制药有限公司 | 2019-06-21 | — | — | CN | claimed |
| CN-109232611-A | A kind of synthetic method of cefotaxime impurity H | 上海上药新亚药业有限公司 | 2019-01-18 | — | — | CN | claimed |
| CN-108558908-A | A kind of desalination method of ceftazidime mother liquor and the preparation method of cefotaxime | 华北制药河北华民药业有限责任公司 | 2018-09-21 | — | — | CN | claimed |
| CN-107722040-A | A kind of membrane separating method and device for recycling ceftazidime mother liquor | 南京志坤环保科技有限公司 | 2018-02-23 | — | — | CN | claimed |
| CN-105646541-B | A kind of former development quality cefotaxime and its pharmaceutical preparation | 广东金城金素制药有限公司 | 2018-01-30 | — | — | CN | claimed |
| CN-106336418-A | Solid phase synthesis method of ceftazidime hydrochloride | 上海上药新亚药业有限公司 | 2017-01-18 | — | — | CN | claimed |
| CN-108383857-B | Preparation method of cefmenoxime hydrochloride | 山东四环药业股份有限公司 | 2021-02-05 | — | — | CN | disclosed |
| CN-108440570-B | Preparation method of ceftiofur ester compound or halogen salt thereof | 济宁市化工研究院 | 2020-12-04 | — | — | CN | disclosed |
| CN-108558908-B | A kind of desalination method of ceftazidime mother liquor and the preparation method of cefotaxime | 华北制药河北华民药业有限责任公司 | 2019-11-29 | — | — | CN | disclosed |
| CN-108558908-B | A kind of desalination method of ceftazidime mother liquor and the preparation method of cefotaxime | 华北制药河北华民药业有限责任公司 | 2019-11-29 | — | — | CN | disclosed |
| CN-109912625-A | A kind of process reducing cefotaxime impurity H | 辽宁美亚制药有限公司 | 2019-06-21 | — | — | CN | disclosed |
| CN-106336418-B | A kind of solid-phase synthesis of cefotaxime hydrochloride | 上海上药新亚药业有限公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-100537768-C | The preparation method of the plant that growth is improved under the nitrogen restricted condition | AJINOMOTO KK (JP) | 2009-09-09 | — | — | CN | disclosed |
| CN-1822763-A | Method of constructing plant showing improved growtn under regulation of nitrogen | AJINOMOTO KK (JP) | 2006-08-23 | — | — | CN | disclosed |
| US-20060090219-A1 | Methods for producing plants with improved growth under nitrogen-limited conditions | AJINOMOTO CO., INC. (JP) | 2006-04-27 | — | — | US | disclosed |
| EP-1647181-A1 | METHOD OF CONSTRUCTING PLANT SHOWING IMPROVED GROWTN UNDER REGULATION OF NITROGEN | Ajinomoto Co., Inc. (JP) | 2006-04-19 | — | — | EP | disclosed |
| US-20050183168-A1 | Plants having decreased dormancy period and methods producing the plants | AJINOMOTO CO., INC. (JP) | 2005-08-18 | — | — | US | disclosed |
| CN-1095670-C | A package from for bicarbonate-containing powdery pharmaceutical compositions and a method of stabilizing the compositions | OTSUKA PHARMA CO LTD (JP) | 2002-12-11 | — | — | CN | disclosed |
| US-5359057-A | Reacting 6-aminopenicillin derivative in the form of an acid addition salt with 2-benzothiazolyl thioester derivative to form amide of penecillin or cephalosporin derivatives; microbiocides | HOFFMANN-LA ROCHE INC. (US) | 1994-10-25 | — | — | US | disclosed |