Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18222537 | 0.77 | LMNA (0.40) | MAPTPOLBLMNAHTTKDM4E | |
| SCHEMBL29168008 | 0.77 | LMNA (0.37) | MAPTPOLBLMNAHTTKDM4E | |
| SCHEMBL1780648 | 0.77 | LMNA (0.40) | MAPTPOLBLMNAHTTKDM4E | |
| SCHEMBL15417666 | 0.77 | LMNA (0.43) | MAPTPOLBLMNAHTTKDM4E | |
| SCHEMBL10716962 | 0.76 | POLB (0.39) | MAPTPOLBLMNAHTTKDM4E | |
| SCHEMBL13270149 | 0.74 | LMNA (0.41) | MAPTPOLBLMNAHTTKDM4E | |
| SCHEMBL5632040 | 0.74 | POLB (0.39) | MAPTPOLBLMNAHTTKDM4E | |
| SCHEMBL24777113 | 0.72 | POLB (0.41) | MAPTPOLBLMNAHTTKDM4E | |
| SCHEMBL18775161 | 0.72 | IRAK4 (0.41) | MAPTPOLBLMNAHTTKDM4E | |
| SCHEMBL2185765 | 0.72 | AR (0.39) | MAPTPOLBLMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1710234-A1 | MALONONITRILE COMPOUND AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2006-10-11 | — | — | EP | disclosed |