Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 20/20 | 0.51 |
| ▸ | MMP2 | P08253 | 18/20 | 0.51 |
| ▸ | MMP9 | P14780 | 13/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.50 |
| ▸ | MMP3 | P08254 | 8/20 | 0.50 |
| ▸ | MMP12 | P39900 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.50 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.50 |
| ▸ | MMP1 | P03956 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4536939 | 1.00 | ADAM10 (0.51) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL5038314 | 0.93 | ADAM10 (0.52) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL5039536 | 0.93 | ADAM10 (0.52) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL5045222 | 0.91 | ADAM10 (0.63) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL4537261 | 0.90 | ADAM10 (0.60) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL4530938 | 0.90 | ADAM10 (0.60) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL5039435 | 0.89 | ADAM10 (0.54) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL5038402 | 0.88 | ADAM10 (0.46) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL5038591 | 0.87 | ADAM10 (0.56) | ADAM10MMP2MMP9ERBB2MMP3 | |
| SCHEMBL5039057 | 0.86 | ADAM10 (0.52) | ADAM10MMP2MMP9ERBB2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613269-A2 | COMPOSITIONS, METHODS AND KITS RELATING TO HER-2 CLEAVAGE | Incyte Corporation (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004089294-A2 | COMPOSITIONS, METHODS AND KITS RELATING TO HER-2 CLEAVAGE | INCYTE CORPORATION (US) | 2004-10-21 | — | — | WO | disclosed |