Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.40 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.40 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6779 | 0.91 | LPAR1 (0.42) | LPAR1ALDH1A1L3MBTL1LPAR3PPARG | |
| SCHEMBL7481 | 0.89 | LPAR1 (0.55) | LPAR1ALDH1A1GAAL3MBTL1LPAR3 | |
| SCHEMBL6023 | 0.84 | LPAR1 (0.42) | LPAR1ALDH1A1SMN1; SMN2GAAL3MBTL1 | |
| SCHEMBL6581 | 0.84 | CHRM1 (0.40) | LPAR1ALDH1A1L3MBTL1LPAR3PPARG | |
| SCHEMBL6889 | 0.84 | FFAR1 (0.46) | LPAR1ALDH1A1L3MBTL1LPAR3LPAR2 | |
| SCHEMBL7143 | 0.83 | LPAR1 (0.41) | LPAR1ALDH1A1GAAL3MBTL1LPAR3 | |
| SCHEMBL1841 | 0.81 | ABCC3 (0.48) | LPAR1ALDH1A1L3MBTL1TSHR | |
| SCHEMBL6482 | 0.81 | LPAR1 (0.41) | LPAR1ALDH1A1GAAL3MBTL1LPAR3 | |
| SCHEMBL18597759 | 0.80 | LPAR1 (0.42) | LPAR1ALDH1A1SMN1; SMN2L3MBTL1LPAR3 | |
| SCHEMBL7190 | 0.80 | LPAR1 (0.40) | LPAR1ALDH1A1SMN1; SMN2L3MBTL1LPAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |