Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7250 | 0.91 | PPARG (0.46) | PPARGPPARALPAR1L3MBTL1ALDH1A1 | |
| SCHEMBL6580 | 0.87 | PPARG (0.42) | CHRM1PPARGPPARALPAR1ALDH1A1 | |
| SCHEMBL6024 | 0.84 | LPAR1 (0.46) | PPARGPPARALPAR1L3MBTL1ALDH1A1 | |
| SCHEMBL6889 | 0.83 | FFAR1 (0.46) | PPARGPPARALPAR1L3MBTL1ALDH1A1 | |
| SCHEMBL7117 | 0.83 | LPAR1 (0.39) | CHRM1PPARGLPAR1L3MBTL1ALDH1A1 | |
| SCHEMBL6779 | 0.83 | LPAR1 (0.42) | PPARGPPARALPAR1L3MBTL1ALDH1A1 | |
| SCHEMBL7242 | 0.81 | LIPG (0.44) | PPARGPPARALPAR1S1PR1S1PR3 | |
| SCHEMBL7481 | 0.80 | LPAR1 (0.55) | LPAR1L3MBTL1ALDH1A1S1PR1S1PR3 | |
| SCHEMBL1841 | 0.79 | ABCC3 (0.48) | LPAR1L3MBTL1ALDH1A1 | |
| SCHEMBL6966 | 0.79 | EPHX2 (0.35) | PPARGLPAR1L3MBTL1ALDH1A1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |