Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 20/20 | 0.68 |
| ▸ | NR1H3 | Q13133 | 19/20 | 0.68 |
| ▸ | PPARG | P37231 | 1/20 | 0.68 |
| ▸ | PPARD | Q03181 | 1/20 | 0.68 |
| ▸ | PPARA | Q07869 | 1/20 | 0.68 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6024014 | 0.93 | NR1H2 (0.79) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1124826 | 0.89 | NR1H2 (0.85) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1126592 | 0.81 | NR1H2 (0.68) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1124477 | 0.81 | NR1H2 (1.00) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL30277838 | 0.81 | NR1H2 (1.00) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL5311335 | 0.81 | NR1H2 (0.83) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125464 | 0.81 | NR1H2 (0.81) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL6025545 | 0.81 | NR1H2 (0.65) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125186 | 0.80 | NR1H2 (0.79) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL5336135 | 0.80 | NR1H2 (0.66) | NR1H2NR1H3PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692111-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | Wyeth, A Corporation of the State of Delaware (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005058834-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | WYETH (US) | 2005-06-30 | — | — | WO | disclosed |