Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 20/20 | 1.00 |
| ▸ | NR1H3 | Q13133 | 20/20 | 1.00 |
| ▸ | PPARG | P37231 | 2/20 | 1.00 |
| ▸ | PPARD | Q03181 | 2/20 | 1.00 |
| ▸ | PPARA | Q07869 | 2/20 | 1.00 |
| ▸ | RXRA | P19793 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30277838 | 1.00 | NR1H2 (1.00) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125273 | 0.95 | NR1H2 (0.90) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125492 | 0.94 | NR1H2 (0.89) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125903 | 0.93 | NR1H2 (0.87) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1124826 | 0.92 | NR1H2 (0.85) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125566 | 0.91 | NR1H2 (0.84) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL4267104 | 0.91 | NR1H2 (0.84) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL5311335 | 0.91 | NR1H2 (0.83) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125464 | 0.90 | NR1H2 (0.81) | NR1H2NR1H3PPARGPPARDPPARA | |
| SCHEMBL1125170 | 0.89 | NR1H2 (0.80) | NR1H2NR1H3PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2284157-A1 | Quinolines useful in treating cardiovascular disease | Wyeth (US) | 2011-02-16 | — | — | EP | claimed |
| US-7576215-B2 | Quinolines and pharmaceutical compositions thereof | WYETH (US) | 2009-08-18 | — | — | US | claimed |
| JP-2007516258-A | — | — | 2007-06-21 | — | — | JP | claimed |
| EP-1692111-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | Wyeth, A Corporation of the State of Delaware (US) | 2006-08-23 | — | — | EP | claimed |
| WO-2005058834-A2 | QUINOLINES USEFUL IN TREATING CARDIOVASCULAR DISEASE | WYETH (US) | 2005-06-30 | — | — | WO | claimed |
| US-20050131014-A1 | Quinolines useful in treating cardiovascular disease | WYETH (US) | 2005-06-16 | — | — | US | claimed |
| US-20230338314-A1 | METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS | THE ROCKEFELLER UNIVERSITY (US) | 2023-10-26 | — | — | US | disclosed |
| US-11648220-B2 | Methods for the treatment of myeloid derived suppressor cells related disorders | THE ROCKEFELLER UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
| US-20210220306-A1 | TREATMENT AND DIAGNOSIS OF MELANOMA | THE ROCKEFELLER UNIVERSITY | 2021-07-22 | — | — | US | disclosed |
| US-10945978-B2 | Treatment and diagnosis of melanoma | THE ROCKEFELLER UNIVERSITY (US) | 2021-03-16 | — | — | US | disclosed |
| US-20200230090-A1 | TREATMENT AND DIAGNOSIS OF MELANOMA | THE ROCKEFELLER UNIVERSITY (US) | 2020-07-23 | — | — | US | disclosed |
| US-10543183-B2 | Treatment and diagnosis of melanoma | THE ROCKEFELLER UNIVERSITY (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190029984-A1 | METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS | THE ROCKEFELLER UNIVERSITY (US) | 2019-01-31 | — | — | US | disclosed |
| US-20090012053-A1 | Use of LXR agonists for the treatment of osteoarthritis | WYETH (US) | 2009-01-08 | — | — | US | disclosed |
| WO-2007050271-A2 | 5-LIPOXYGENASE MODULATORS | WYETH (US) | 2007-05-03 | — | — | WO | disclosed |
| WO-2007050271-A2 | 5-LIPOXYGENASE MODULATORS | WYETH (US) | 2007-05-03 | — | — | WO | disclosed |
| US-20070093524-A1 | 5-Lipoxygenase modulators | WYETH (US) | 2007-04-26 | — | — | US | disclosed |
| US-20070093524-A1 | 5-Lipoxygenase modulators | WYETH (US) | 2007-04-26 | — | — | US | disclosed |
| US-20070093524-A1 | 5-Lipoxygenase modulators | WYETH (US) | 2007-04-26 | — | — | US | disclosed |
| US-20050131014-A1 | Quinolines useful in treating cardiovascular disease | WYETH (US) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10543183-B2 | Treatment and diagnosis of melanoma | EYA3, BRAF, CD99 | NR1H2 4537/4885NR1H3 4400/4885PPARG 4683/4885 |
| US-10945978-B2 | Treatment and diagnosis of melanoma | EYA3, BRAF, CD99 | NR1H2 4537/4885NR1H3 4400/4885PPARG 4683/4885 |
| US-20090012053-A1 | Use of LXR agonists for the treatment of osteoarthritis | NR1H2, NR1H3, PPARG | NR1H2 1/4885NR1H3 2/4885PPARG 3/4885 |
| US-11648220-B2 | Methods for the treatment of myeloid derived suppressor cells related disorders | NR1H3, NR1H2, MCL1 | NR1H2 2/4885NR1H3 1/4885PPARG 131/4885 |
| US-20230338314-A1 | METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS | NR1H3, NR1H2, MCL1 | NR1H2 2/4885NR1H3 1/4885PPARG 131/4885 |
| US-20210220306-A1 | TREATMENT AND DIAGNOSIS OF MELANOMA | EYA3, BRAF, CD99 | NR1H2 4537/4885NR1H3 4400/4885PPARG 4683/4885 |
| US-20190029984-A1 | METHODS FOR THE TREATMENT OF MYELOID DERIVED SUPPRESSOR CELLS RELATED DISORDERS | NR1H3, NR1H2, MCL1 | NR1H2 2/4885NR1H3 1/4885PPARG 131/4885 |
| US-20070093524-A1 | 5-Lipoxygenase modulators | ALOX5, ALOX15, ALOX15B | NR1H2 6/4885NR1H3 8/4885PPARG 335/4885 |
| US-20200230090-A1 | TREATMENT AND DIAGNOSIS OF MELANOMA | EYA3, BRAF, CD99 | NR1H2 4537/4885NR1H3 4400/4885PPARG 4683/4885 |
| US-20050131014-A1 | Quinolines useful in treating cardiovascular disease | NR1H2, NR1H3, SREBF1 | NR1H2 1/4885NR1H3 2/4885PPARG 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.