Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 19/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602825 | 0.93 | GPBAR1 (0.52) | GPBAR1NR1H4L3MBTL1 | |
| SCHEMBL10228774 | 0.92 | GPBAR1 (0.53) | GPBAR1NR1H4 | |
| SCHEMBL604771 | 0.90 | GPBAR1 (0.57) | GPBAR1NR1H4 | |
| SCHEMBL601604 | 0.89 | GPBAR1 (0.54) | GPBAR1NR1H4 | |
| SCHEMBL601196 | 0.88 | GPBAR1 (0.60) | GPBAR1NR1H4 | |
| SCHEMBL601617 | 0.88 | GPBAR1 (0.53) | GPBAR1NR1H4 | |
| SCHEMBL604194 | 0.86 | GPBAR1 (0.57) | GPBAR1NR1H4 | |
| SCHEMBL602844 | 0.86 | GPBAR1 (0.55) | GPBAR1NR1H4 | |
| SCHEMBL605167 | 0.86 | GPBAR1 (0.52) | GPBAR1NR1H4 | |
| SCHEMBL10227731 | 0.86 | GPBAR1 (0.56) | GPBAR1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785488-B2 | Triazole and imidazole derivatives for use as TGR5 agonists in the treatment of diabetes and obesity | EXELIXIS PATENT COMPANY LLC (US) | 2014-07-22 | — | — | US | claimed |
| US-20120040985-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | EXELIXIS PATENT COMPANY LLC (US) | 2012-02-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120040985-A1 | TRIAZOLE AND IMIDAZOLE DERIVATIVES FOR USE AS TGR5 AGONISTS IN THE TREATMENT OF DIABETES AND OBESITY | GPR119, GLP1R, GCGR | GPBAR1 8/4885NR1H4 53/4885L3MBTL1 4174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.