Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26601966 | 0.82 | LMNA (0.56) | SMN1; SMN2LMNAKDM4EKDM5AKDM5B | |
| SCHEMBL15331979 | 0.82 | SMN1; SMN2 (1.00) | SMN1; SMN2USP2CYP3A4LMNAKDM4E | |
| SCHEMBL5188877 | 0.81 | CYP1A2 (0.60) | SMN1; SMN2LMNAKDM4EKDM5AKDM5B | |
| SCHEMBL6023616 | 0.78 | LMNA (0.52) | SMN1; SMN2LMNAKDM4EKDM5AKDM5B | |
| SCHEMBL8545504 | 0.75 | HPGD (0.56) | SMN1; SMN2USP2LMNAKDM4EALDH1A1 | |
| SCHEMBL2010227 | 0.74 | CYP1A2 (0.52) | SMN1; SMN2LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL68410 | 0.73 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL1801531 | 0.72 | HPGD (0.69) | SMN1; SMN2LMNAALDH1A1HPGDKMT2A | |
| SCHEMBL11789541 | 0.72 | SMN1; SMN2 (0.65) | SMN1; SMN2LMNAKDM4EALDH1A1HPGD | |
| Ethyl Hematommate SCHEMBL31350971 | 0.72 | CYP3A4 (1.00) | SMN1; SMN2USP2CYP3A4LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115608-B2 | Pyridinone and pyridinethione derivatives having HIV inhibiting properties | CENTRE NATIONAL DE LA RECHERCHE SCHENTIFIQUE (FR) | 2006-10-03 | — | — | US | disclosed |
| EP-1318995-B1 | PYRIDINONE AND PYRIDINETHIONE DERIVATIVES HAVING HIV INHIBITING PROPERTIES | CENTRE NAT RECH SCIENT (FR) | 2006-03-08 | — | — | EP | disclosed |
| US-20040229847-A1 | Pyridinone and pyridinethione derivatives having hiv inhibiting properties | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2004-11-18 | — | — | US | disclosed |
| EP-1318995-A2 | PYRIDINONE AND PYRIDINETHIONE DERIVATIVES HAVING HIV INHIBITING PROPERTIES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2003-06-18 | — | — | EP | disclosed |
| WO-2002024650-A2 | PYRIDINONE AND PYRIDINETHIONE DERIVATIVES HAVING HIV INHIBITING PROPERTIES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229847-A1 | Pyridinone and pyridinethione derivatives having hiv inhibiting properties | CYP2B6, CYP2S1, CYP2D6 | SMN1; SMN2 4627/4885USP2 4294/4885CYP3A4 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.