Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 13/20 | 0.43 |
| ▸ | MMP2 | P08253 | 8/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5621610 | 1.00 | ADAM10 (0.43) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL6023784 | 0.83 | ADAM10 (0.52) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL5038238 | 0.82 | ADAM10 (0.64) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL5039259 | 0.82 | ADAM10 (0.64) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL2175433 | 0.77 | ADAM10 (0.71) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL2171652 | 0.77 | ADAM10 (0.71) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL6024795 | 0.77 | ADAM10 (0.33) | ADAM10MMP2MMP9MMP3F2 | |
| SCHEMBL5035330 | 0.77 | ADAM10 (0.53) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL5623156 | 0.74 | ADAM10 (0.64) | ADAM10MMP2MMP9MMP3ERBB2 | |
| SCHEMBL5622617 | 0.73 | ADAM10 (0.53) | ADAM10MMP2MMP9MMP3ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |