Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 14/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.51 |
| ▸ | MMP2 | P08253 | 11/20 | 0.46 |
| ▸ | MMP9 | P14780 | 7/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 4/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457323 | 0.89 | ADAM10 (0.55) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL5623013 | 0.88 | ADAM10 (0.52) | ADAM10ERBB2MMP2MMP9NPC1 | |
| SCHEMBL6024732 | 0.86 | ADAM10 (0.53) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL5622579 | 0.85 | ADAM10 (0.53) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL5623179 | 0.85 | ADAM10 (0.54) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL5621932 | 0.84 | ADAM10 (0.53) | ADAM10ERBB2MMP2MMP9MMP3 | |
| SCHEMBL6025016 | 0.83 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL6025097 | 0.82 | ADAM10 (0.51) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL6024991 | 0.82 | ADAM10 (0.54) | ADAM10ERBB2MMP2MMP9CTSB | |
| SCHEMBL6024771 | 0.81 | ADAM10 (0.50) | ADAM10ERBB2MMP2MMP9CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |