SCHEMBL6024476

SCHEMBL6024476

Fc1ccc(C2CNCC23CCNCC3)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LIG1 P18858 1/20 0.38
KDM1A O60341 1/20 0.35
RCOR1 Q9UKL0 1/20 0.35
SLC6A2 P23975 4/20 0.35
SLC6A4 P31645 4/20 0.35
SLC6A3 Q01959 4/20 0.35
TDP1 Q9NUW8 1/20 0.34
SLC6A9 P48067 6/20 0.33
OPRM1 P35372 4/20 0.33
SLC6A5 Q9Y345 3/20 0.33
KCNH2 Q12809 1/20 0.33
HTR1A P08908 1/20 0.33
HTR1D P28221 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR1E P28566 1/20 0.33
HTR7 P34969 1/20 0.33
HTR2B P41595 1/20 0.33
HTR6 P50406 1/20 0.33
RECQL P46063 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6025232 1.00 LIG1 (0.38) LIG1KDM1ARCOR1SLC6A2SLC6A4
SCHEMBL6025678 1.00 LIG1 (0.38) LIG1KDM1ARCOR1SLC6A2SLC6A4
SCHEMBL31088483 0.88 LIG1 (0.46) LIG1KDM1ARCOR1SLC6A2SLC6A4
SCHEMBL17725393 0.81 LIG1 (0.42) LIG1KDM1ARCOR1SLC6A2SLC6A4
SCHEMBL21418957 0.81 LIG1 (0.42) LIG1KDM1ARCOR1SLC6A2SLC6A4
SCHEMBL23466168 0.81 LIG1 (0.42) LIG1KDM1ARCOR1SLC6A2SLC6A4
SCHEMBL19629557 0.81 LIG1 (0.42) LIG1KDM1ARCOR1SLC6A2SLC6A4
SCHEMBL21418971 0.81 LIG1 (0.42) LIG1KDM1ARCOR1SLC6A2SLC6A4
SCHEMBL17725137 0.81 LIG1 (0.42) LIG1KDM1ARCOR1SLC6A2SLC6A4
SCHEMBL19626353 0.81 LIG1 (0.42) LIG1KDM1ARCOR1SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1716147-A1 DIAZA-SPIROPIPERIDINE DERIVATIVES AS INHIBITORS OF GLYCINE TRANSPORTER 1 AND GLYCINE TRANSPORTER 2 F.HOFFMANN-LA ROCHE AG (CH) 2006-11-02 EP disclosed
WO-2005068462-A1 DIAZA-SPIROPIPERIDINE DERIVATIVES AS INHIBITORS OF TRANSPORTER 1 AND GLYCINE TRANSPORTER 2 F. HOFFMANN-LA ROCHE AG (CH) 2005-07-28 WO disclosed