Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | ADAM10 | O14672 | 2/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457479 | 1.00 | USP30 (0.41) | USP30ADAM10ERBB2RAB9AALDH1A1 | |
| SCHEMBL3457481 | 1.00 | USP30 (0.41) | USP30ADAM10ERBB2RAB9AALDH1A1 | |
| SCHEMBL2174428 | 0.91 | ADAM10 (0.42) | USP30ADAM10ERBB2RAB9AALDH1A1 | |
| SCHEMBL2174431 | 0.83 | ADAM10 (0.41) | USP30ADAM10ERBB2RAB9AALDH1A1 | |
| SCHEMBL6024319 | 0.77 | POLB (0.37) | ADAM10ALDH1A1POLBKMT2AHTT | |
| SCHEMBL3456956 | 0.77 | POLB (0.37) | ADAM10ALDH1A1POLBKMT2AHTT | |
| SCHEMBL3456952 | 0.77 | POLB (0.37) | ADAM10ALDH1A1POLBKMT2AHTT | |
| SCHEMBL2171983 | 0.76 | ADAM10 (0.44) | USP30ADAM10ERBB2RAB9AALDH1A1 | |
| SCHEMBL6023763 | 0.76 | ADAM10 (0.44) | USP30ADAM10ERBB2RAB9AALDH1A1 | |
| SCHEMBL5622655 | 0.75 | ADAM10 (0.55) | USP30ADAM10ERBB2RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |