Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | MARS1 | P56192 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3364574 | 0.90 | CRHR1 (0.50) | CRHR1HSD11B1 | |
| SCHEMBL3366185 | 0.88 | CRHR1 (0.48) | CRHR1HSD11B1 | |
| SCHEMBL3839128 | 0.86 | CRHR1 (0.51) | CRHR1HSD11B1 | |
| SCHEMBL7059971 | 0.86 | CRHR1 (0.46) | CRHR1HSD11B1 | |
| SCHEMBL3364753 | 0.85 | CRHR1 (0.50) | CRHR1HSD11B1 | |
| SCHEMBL3841160 | 0.85 | CRHR1 (0.45) | CRHR1HSD11B1 | |
| SCHEMBL3839759 | 0.84 | CRHR1 (0.39) | CRHR1HSD11B1MARS1 | |
| SCHEMBL3364556 | 0.83 | CRHR1 (0.49) | CRHR1HSD11B1 | |
| SCHEMBL3364016 | 0.83 | CRHR1 (0.48) | CRHR1HSD11B1 | |
| SCHEMBL3364586 | 0.83 | CRHR1 (0.48) | CRHR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656353-A1 | GABANERGIC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-05-17 | — | — | EP | disclosed |
| WO-2005016892-A1 | GABANERGIC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-02-24 | — | — | WO | disclosed |