SCHEMBL6024895

SCHEMBL6024895

COCCOC(=O)C(=NO)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.49
TSHR P16473 3/20 0.49
GAA P10253 3/20 0.47
CYP2C19 P33261 1/20 0.47
LMNA P02545 3/20 0.45
KMT2A Q03164 2/20 0.45
KDM4E B2RXH2 1/20 0.45
HSP90AA1 P07900 1/20 0.45
MAPT P10636 1/20 0.45
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
HPGD P15428 1/20 0.42
TDP1 Q9NUW8 2/20 0.40
POLB P06746 2/20 0.40
CA2 P00918 1/20 0.40
AKT1 P31749 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6024888 1.00 SMN1; SMN2 (0.49) SMN1; SMN2TSHRGAACYP2C19LMNA
SCHEMBL6024589 0.80 TSHR (0.53) SMN1; SMN2TSHRLMNAKDM4EMAPT
SCHEMBL6024586 0.80 TSHR (0.53) SMN1; SMN2TSHRLMNAKDM4EMAPT
SCHEMBL6025239 0.80 TSHR (0.55) TSHRLMNAKMT2AKDM4EHSP90AA1
SCHEMBL6025442 0.79 GAA (0.57) SMN1; SMN2TSHRGAACYP2C19LMNA
SCHEMBL6157370 0.79 GAA (0.57) SMN1; SMN2TSHRGAACYP2C19LMNA
SCHEMBL6025444 0.79 GAA (0.57) SMN1; SMN2TSHRGAACYP2C19LMNA
SCHEMBL14839252 0.78 MAPT (0.51) SMN1; SMN2TSHRGAACYP2C19KMT2A
SCHEMBL27849629 0.76 TSHR (0.46) SMN1; SMN2TSHRGAALMNAKMT2A
SCHEMBL514995 0.75 TSHR (0.69) SMN1; SMN2TSHRLMNAKMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1163553-B1 OXIME DERIVATIVES AND THE USE THEREOF AS PHOTOINITIATORS CIBA SC HOLDING AG (CH) 2006-06-14 EP disclosed
EP-1635220-A2 Oxime derivatives and the use thereof as photoinitiators Ciba Specialty Chemicals Holding Inc. (CH) 2006-03-15 EP disclosed
US-6806024-B1 MIXTURES OF ADDITION POLYMERS AND ACTIVATORS COMPRISING NITROGEN COMPOUNDS, USED AS SUBSTRATE COATINGS FOR COLOR FILTERS CIBA SPECIALTY CHEMICALS CORPORATION 2004-10-19 US disclosed
EP-1163553-A1 OXIME DERIVATIVES AND THE USE THEREOF AS PHOTOINITIATORS Ciba SC Holding AG (CH) 2001-12-19 EP disclosed
WO-2000052530-A1 OXIME DERIVATIVES AND THE USE THEREOF AS PHOTOINITIATORS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2000-09-08 WO disclosed