Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 11/20 | 0.70 |
| ▸ | SLC6A5 | Q9Y345 | 10/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | IDE | P14735 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5399449 | 1.00 | SLC6A9 (0.70) | SLC6A9SLC6A5ALDH1A1MEN1KMT2A | |
| SCHEMBL5394474 | 0.99 | SLC6A9 (0.68) | SLC6A9SLC6A5ALDH1A1MEN1KMT2A | |
| SCHEMBL5399614 | 0.92 | SLC6A9 (0.67) | SLC6A9SLC6A5ALDH1A1MEN1KMT2A | |
| SCHEMBL6011895 | 0.91 | POLB (0.68) | SLC6A9SLC6A5ALDH1A1MEN1KMT2A | |
| SCHEMBL5397289 | 0.91 | SLC6A9 (0.71) | SLC6A9SLC6A5SMN1; SMN2IDE | |
| SCHEMBL5401512 | 0.91 | SLC6A9 (0.65) | SLC6A9SLC6A5ALDH1A1MEN1KMT2A | |
| SCHEMBL5401613 | 0.90 | SLC6A9 (0.57) | SLC6A9SLC6A5ALDH1A1MEN1KMT2A | |
| SCHEMBL6024299 | 0.89 | SLC6A9 (0.58) | SLC6A9SLC6A5ALDH1A1MEN1KMT2A | |
| SCHEMBL5393966 | 0.89 | SLC6A9 (0.59) | SLC6A9SLC6A5ALDH1A1MEN1KMT2A | |
| SCHEMBL6011826 | 0.89 | POLB (0.57) | SLC6A9SLC6A5ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663232-A1 | 1-(2-AMINO-BENZOYL)-PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005023260-A1 | 1- (2-AMINO-BENZOL) -PIPERAZINE DERIVATIVES AS GLYCINE UPTAKE INHIBITORS FOR THE TREATMENT OF PSYCHOSES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-17 | — | — | WO | disclosed |