Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432470 | 0.80 | CYP2C19 (0.51) | MAP4K1MAOAMAOBGRM5ALDH1A1 | |
| SCHEMBL4427130 | 0.80 | MAP4K1 (0.47) | MAP4K1MAOAMAOBGRM5ALDH1A1 | |
| SCHEMBL4424635 | 0.79 | MAP4K1 (0.48) | MAP4K1MAOAMAOBGRM5ALDH1A1 | |
| SCHEMBL4423359 | 0.77 | MAP4K1 (0.52) | MAP4K1MAOAMAOBGRM5ALDH1A1 | |
| SCHEMBL4430358 | 0.76 | KMT2A (0.53) | MAP4K1MAOAMAOBALDH1A1NPC1 | |
| SCHEMBL4432318 | 0.76 | CYP2C19 (0.55) | MAP4K1MAOAMAOBGRM5ALDH1A1 | |
| SCHEMBL4424753 | 0.74 | MAOA (0.55) | MAP4K1MAOAMAOBGRM5ALDH1A1 | |
| SCHEMBL4430352 | 0.74 | CYP2C19 (0.52) | MAP4K1MAOAMAOBGRM5ALDH1A1 | |
| SCHEMBL4425787 | 0.72 | MAP4K1 (0.45) | MAP4K1MAOAMAOBGRM5ALDH1A1 | |
| SCHEMBL4424035 | 0.71 | MAOA (0.44) | MAP4K1MAOAMAOBGRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723116-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co. KGaA (DE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005082856-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2005-09-09 | — | — | WO | disclosed |