Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAC1 | P63000 | 2/20 | 0.55 |
| ▸ | RAC2 | P15153 | 1/20 | 0.55 |
| ▸ | RAC3 | P60763 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027115 | 0.92 | RAC1 (0.66) | RAC1RAC2RAC3PDK2KMT2A | |
| SCHEMBL1461454 | 0.91 | RAC1 (0.53) | RAC1RAC2RAC3KMT2AL3MBTL1 | |
| SCHEMBL6026739 | 0.86 | RAC1 (0.52) | RAC1RAC2RAC3PDK2KMT2A | |
| SCHEMBL4168881 | 0.84 | RAC1 (0.68) | RAC1RAC2RAC3PDK2KMT2A | |
| SCHEMBL1462439 | 0.84 | RAC1 (0.62) | RAC1RAC2RAC3KMT2A | |
| SCHEMBL1461829 | 0.80 | RAC1 (0.84) | RAC1RAC2RAC3PDK2KMT2A | |
| SCHEMBL6026588 | 0.79 | RAC1 (0.61) | RAC1RAC2RAC3PDK2KMT2A | |
| Hydrochloric Acid SCHEMBL1461295 | 0.79 | RAC1 (0.85) | RAC1RAC2RAC3PDK2KMT2A | |
| SCHEMBL4421433 | 0.78 | THRB (0.45) | RAC1RAC2RAC3KMT2AL3MBTL1 | |
| SCHEMBL4161227 | 0.75 | RAC1 (0.81) | RAC1RAC2RAC3PDK2LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597253-B1 | COMPOUNDS AND METHODS OF TREATING CELL PROLIFERATIVE DISEASES, RETINOPATHIES AND ARTHRITIS | EXONHIT THERAPEUTICS SA (FR) | 2006-08-09 | — | — | EP | claimed |
| EP-1597253-B1 | COMPOUNDS AND METHODS OF TREATING CELL PROLIFERATIVE DISEASES, RETINOPATHIES AND ARTHRITIS | EXONHIT THERAPEUTICS SA (FR) | 2006-08-09 | — | — | EP | disclosed |