Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 4/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038584 | 0.91 | GRK6 (0.44) | GRK6CNR2OGFRL1OPRM1OPRK1 | |
| SCHEMBL2681871 | 0.85 | CNR2 (0.50) | GRK6CNR2OGFRL1OPRM1OPRK1 | |
| SCHEMBL5048090 | 0.82 | CNR2 (0.34) | CNR2ALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL6026302 | 0.73 | GRK6 (0.33) | GRK6CNR2OGFRL1OPRM1OPRK1 | |
| SCHEMBL4734637 | 0.71 | CNR2 (0.48) | CNR2OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL14886782 | 0.68 | HPGD (0.38) | ALDH1A1KDM4EHPGDCYP1A2KMT2A | |
| SCHEMBL12926023 | 0.68 | KMT2A (0.46) | ALDH1A1KDM4EHPGDCYP1A2KMT2A | |
| SCHEMBL16268486 | 0.68 | GRK6 (0.42) | GRK6OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL30668018 | 0.66 | GRK6 (0.43) | GRK6OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL20386876 | 0.64 | KMT2A (0.43) | ALDH1A1CYP1A2KMT2ATP53ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644351-A1 | IMIDAZOLE DERIVATIVES III | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005003117-A1 | IMIDAZOLE DERIVATIVES III | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-13 | — | — | WO | disclosed |