Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.68 |
| ▸ | ESR1 | P03372 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12942778 | 1.00 | LMNA (0.68) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL13797577 | 1.00 | LMNA (0.68) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL7047055 | 0.85 | LMNA (0.63) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL7047058 | 0.85 | LMNA (0.63) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL12904926 | 0.84 | LMNA (0.67) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL13797574 | 0.84 | LMNA (0.67) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL13768825 | 0.84 | LMNA (0.67) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL923334 | 0.84 | LMNA (0.67) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL11234363 | 0.83 | LMNA (0.72) | LMNAHSD17B10ESR1SMN1; SMN2MAPT | |
| SCHEMBL6025711 | 0.83 | LMNA (0.57) | LMNAHSD17B10ESR1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7015211-B2 | 15α-substituted estradiol carboxylic acid esters as locally active estrogens | YALE UNIVERSITY (US) | 2006-03-21 | — | — | US | disclosed |
| WO-2004085345-A2 | 15α-SUBSTITUTED ESTRADIOL CARBOXYLIC ACID ESTERS AS LOCALLY ACTIVE ESTROGENS | YALE UNIVERSITY (US) | 2004-10-07 | — | — | WO | disclosed |
| US-20040198711-A1 | 15Alpha-substituted estradiol carboxylic acid esters as locally active estrogens | YALE UNIVERSITY | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198711-A1 | 15Alpha-substituted estradiol carboxylic acid esters as locally active estrogens | ESR1, GPER1, ESR2 | LMNA 1792/4885HSD17B10 353/4885ESR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.