SCHEMBL6026490

SCHEMBL6026490

COC(=O)C1C(O)CCN1C(=O)Nc1ccc(C#N)c(Cl)c1C

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 18/20 0.67
PGR P06401 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2955405 1.00 AR (0.67) ARPGR
SCHEMBL13215950 1.00 AR (0.67) ARPGR
SCHEMBL2963011 1.00 AR (0.67) ARPGR
SCHEMBL13216320 1.00 AR (0.67) ARPGR
SCHEMBL6025855 1.00 AR (0.67) ARPGR
SCHEMBL6025293 0.91 AR (0.57) ARPGR
SCHEMBL2956204 0.91 AR (0.57) ARPGR
SCHEMBL13586658 0.83 AR (0.51) AR
SCHEMBL2964783 0.83 AR (0.50) ARPGR
SCHEMBL6094398 0.82 AR (0.48) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506178-A4 BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION BRISTOL MYERS SQUIBB CO (US) 2006-05-24 EP disclosed
EP-1506178-A2 BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION Bristol-Myers Squibb Company (US) 2005-02-16 EP disclosed
WO-2003096980-A2 BICYCLIC MODULATORS OF ANDROGEN RECEPTOR FUNCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2003-11-27 WO disclosed