Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 14/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | CHUK | O15111 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4903401 | 0.88 | IKBKB (0.67) | IKBKBMAPK8MAPK10ALDH1A1CHUK | |
| SCHEMBL7470313 | 0.86 | ABL1 (0.58) | IKBKBMAPK8MAPK10CHUKMEN1 | |
| SCHEMBL4155684 | 0.83 | IKBKB (0.59) | IKBKBMAPK8MAPK10CDK2 | |
| SCHEMBL3518049 | 0.81 | IKBKB (0.79) | IKBKBMAPK8MAPK10CHUKCDK2 | |
| SCHEMBL4666191 | 0.79 | KMT2A (0.71) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL4897551 | 0.79 | ABL1 (0.69) | IKBKB | |
| SCHEMBL24996510 | 0.79 | MAPT (0.74) | ALDH1A1MEN1KMT2AGAALMNA | |
| SCHEMBL4904242 | 0.79 | KIT (0.56) | IKBKBALDH1A1CHUKCDK2 | |
| SCHEMBL8311025 | 0.79 | HTT (0.58) | IKBKBMAPK8MAPK10ALDH1A1CHUK | |
| SCHEMBL4903706 | 0.78 | PRKCA (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709007-A1 | N-4-(6-(HETEO)ARYL-PYRIMIDIN-4-YLAMINOPHENYL)-BENZENESULFONAMIDES AS KINASE INHIBITORS | Altana Pharma AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070900-A1 | N-4-(6- (HETEO) ARYL-PYRIMIDIN-4-YLAMINOPHENYL) -BEZENESULFONAMIDES AS KINASE INHIBITORS | ALTANA PHARMA AG (DE) | 2005-08-04 | — | — | WO | disclosed |