Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | ABL1 | P00519 | 8/20 | 0.56 |
| ▸ | BCR | P11274 | 8/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4666050 | 0.83 | ABL1 (0.71) | CYP1A2CYP2C19CYP3A4CYP2D6CLK4 | |
| SCHEMBL4665750 | 0.82 | CYP1A2 (0.58) | CYP1A2CYP2C19CYP3A4CYP2D6CLK4 | |
| SCHEMBL4665672 | 0.81 | CYP1A2 (0.69) | CYP1A2CYP2C19CYP3A4CYP2D6CLK4 | |
| SCHEMBL4103913 | 0.75 | CYP1A2 (0.52) | CYP1A2CYP2C19CYP3A4CYP2D6CLK4 | |
| SCHEMBL3222813 | 0.75 | EGFR (0.64) | CYP1A2CYP2C19CYP3A4CYP2D6MAPK1 | |
| SCHEMBL5735264 | 0.75 | CYP1A2 (0.58) | CYP1A2CLK4CYP2C9TP53MEN1 | |
| SCHEMBL1013886 | 0.75 | ABL1 (0.67) | CYP1A2CYP2C19CYP3A4CYP2D6CLK4 | |
| SCHEMBL21645363 | 0.75 | KMO (0.65) | CYP1A2CYP2C19CYP3A4CYP2D6CLK4 | |
| SCHEMBL1243788 | 0.75 | NPC1 (0.57) | MEN1KMT2AEGFRERBB3 | |
| SCHEMBL12907689 | 0.74 | CYP1A2 (0.59) | CYP1A2CYP2C19CYP3A4CYP2D6CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709007-A1 | N-4-(6-(HETEO)ARYL-PYRIMIDIN-4-YLAMINOPHENYL)-BENZENESULFONAMIDES AS KINASE INHIBITORS | Altana Pharma AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005070900-A1 | N-4-(6- (HETEO) ARYL-PYRIMIDIN-4-YLAMINOPHENYL) -BEZENESULFONAMIDES AS KINASE INHIBITORS | ALTANA PHARMA AG (DE) | 2005-08-04 | — | — | WO | disclosed |