Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 16/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | MITF | O75030 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | XBP1 | P17861 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.54 |
| ▸ | RXRB | P28702 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tucaresol SCHEMBL600942 | 0.86 | RXRA (0.56) | MRGPRX4NPC1HPGDRAB9AKMT2A | |
| Tucaresol SCHEMBL29400654 | 0.86 | RXRA (0.56) | MRGPRX4NPC1HPGDRAB9AKMT2A | |
| SCHEMBL6027093 | 0.86 | MRGPRX4 (0.55) | MRGPRX4NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL2370214 | 0.84 | MAPT (0.57) | NPC1RAB9ASMN1; SMN2FOLH1 | |
| SCHEMBL31482098 | 0.81 | MRGPRX4 (0.67) | MRGPRX4MEN1NPC1MITFTP53 | |
| SCHEMBL18630426 | 0.81 | F2 (0.45) | MRGPRX4MEN1NPC1MITFTP53 | |
| SCHEMBL30078103 | 0.79 | MRGPRX4 (0.60) | MRGPRX4MEN1NPC1MITFTP53 | |
| SCHEMBL15065649 | 0.79 | MRGPRX4 (0.60) | MRGPRX4MEN1NPC1MITFTP53 | |
| SCHEMBL23383954 | 0.77 | MAOB (0.53) | RAB9AKMT2ASMN1; SMN2RXRARXRB | |
| SCHEMBL6026854 | 0.77 | TP53 (0.58) | MRGPRX4MEN1TP53HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074770-B1 | Method of DNA vaccination | SMITHKLINE BEECHAM CORPORATION (US) | 2006-07-11 | — | — | US | claimed |
| EP-1107785-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2001-06-20 | — | — | EP | claimed |
| WO-2000012121-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2000-03-09 | — | — | WO | claimed |
| US-4410537-A | 3-HYDROXY-2-FORMYLPHENOXYPENTANOIC ACID DERIVATIVES | BURROUGHTS WELLCOME CO. (US) | 1983-10-18 | — | — | US | claimed |
| EP-0022229-B1 | SUBSTITUTED PHENOL ETHERS, THEIR PREPARATION, INTERMEDIATES THEREFOR, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE PREPARATION THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-12-08 | — | — | EP | claimed |
| EP-0022229-A1 | Substituted phenol ethers, their preparation, intermediates therefor, pharmaceutical compositions containing them and the preparation thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-01-14 | — | — | EP | claimed |
| US-7074770-B1 | Method of DNA vaccination | SMITHKLINE BEECHAM CORPORATION (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1107785-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012121-A1 | METHOD OF DNA VACCINATION | GLAXO GROUP LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |
| EP-0614357-A1 | IMMUNOPOTENTIATORY AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-09-14 | — | — | EP | disclosed |
| WO-1994007479-A2 | IMMUNOPOTENTIATORY AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-04-14 | — | — | WO | disclosed |
| US-4410537-A | 3-HYDROXY-2-FORMYLPHENOXYPENTANOIC ACID DERIVATIVES | BURROUGHTS WELLCOME CO. (US) | 1983-10-18 | — | — | US | disclosed |
| EP-0022229-B1 | SUBSTITUTED PHENOL ETHERS, THEIR PREPARATION, INTERMEDIATES THEREFOR, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE PREPARATION THEREOF | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-12-08 | — | — | EP | disclosed |
| EP-0022229-A1 | Substituted phenol ethers, their preparation, intermediates therefor, pharmaceutical compositions containing them and the preparation thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-01-14 | — | — | EP | disclosed |