Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 5/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | LTK | P29376 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5077264 | 0.83 | PARP1 (0.47) | DHODHPARP1MAP4K4CLK4CSNK1G2 | |
| SCHEMBL6028881 | 0.82 | PLK4 (0.45) | DHODHPARP1MAP4K4CLK4PDGFRA | |
| SCHEMBL6028084 | 0.80 | DHODH (0.59) | DHODHPARP1MAP4K4CLK4PDGFRA | |
| SCHEMBL6029606 | 0.79 | DHODH (0.78) | DHODHPARP1MAP4K4CLK4PDGFRA | |
| SCHEMBL6029671 | 0.78 | DHODH (0.68) | DHODHPARP1MAP4K4CLK4PDGFRA | |
| SCHEMBL6029520 | 0.78 | CDC7 (0.62) | DHODHMAP4K4CLK4MKNK2PLK4 | |
| SCHEMBL31127659 | 0.77 | PARP1 (0.54) | PARP1MAP4K4CLK4CSNK1G2MKNK2 | |
| SCHEMBL995473 | 0.77 | PARP1 (0.54) | PARP1MAP4K4CLK4CSNK1G2MKNK2 | |
| SCHEMBL6028712 | 0.77 | DHODH (0.46) | DHODHPARP1MAP4K4CLK4CSNK1G2 | |
| SCHEMBL6029110 | 0.77 | BTK (0.57) | DHODHPARP1MAP4K4CLK4MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087637-B2 | Substituted indoles which are PARP inhibitors | BASF AG (DE) | 2006-08-08 | — | — | US | disclosed |
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067949-A1 | Substituted indoles which are parp inhibitors | PARP1, PARP2, PARP12 | DHODH 674/4885PARP1 1/4885MAP4K4 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.