Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.54 |
| ▸ | GAA | P10253 | 8/20 | 0.54 |
| ▸ | HPGD | P15428 | 7/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 4/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027814 | 0.92 | KDM4E (0.49) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL6029643 | 0.91 | KDM4E (0.54) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL6027804 | 0.91 | KDM4E (0.52) | KDM4EALDH1A1GAAHPGDGSK3A | |
| SCHEMBL5822150 | 0.90 | KDM4E (0.51) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL6028402 | 0.90 | KDM4E (0.56) | KDM4EALDH1A1GAAHPGDGSK3A | |
| SCHEMBL5809315 | 0.89 | KDM4E (0.51) | KDM4EALDH1A1GAAHPGDGSK3B | |
| SCHEMBL6028247 | 0.89 | KDM4E (0.56) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL6027973 | 0.88 | KDM4E (0.54) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL6028041 | 0.88 | KDM4E (0.53) | KDM4EALDH1A1GAAHPGDCASP1 | |
| SCHEMBL6029716 | 0.87 | NOTCH1 (0.57) | KDM4EALDH1A1GAAHPGDGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663227-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | Synta Pharmaceuticals Corporation (US) | 2006-06-07 | — | — | EP | claimed |
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SYNTA PHARMACEUTICAL CORP. | 2005-09-15 | — | — | US | claimed |
| WO-2005025507-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | SYNTA PHAMACEUTICALS CORP. (US) | 2005-03-24 | — | — | WO | claimed |
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SYNTA PHARMACEUTICAL CORP. | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203119-A1 | Dihydropyridine compounds for treating or preventing metabolic disorders | SLC5A2, SLC5A1, QDPR | KDM4E 2337/4885ALDH1A1 416/4885GAA 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.