Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.53 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13936940 | 0.77 | UBE2T (0.53) | KMT2AMEN1HPGDALDH1A1CYP1A2 | |
| SCHEMBL77032 | 0.76 | KMT2A (0.68) | KMT2AMEN1HPGDALDH1A1CYP1A2 | |
| SCHEMBL371155 | 0.76 | UBE2T (0.63) | KMT2AMEN1HPGDALDH1A1CYP1A2 | |
| SCHEMBL11207950 | 0.75 | UBE2T (0.54) | KMT2AMEN1HPGDALDH1A1CYP1A2 | |
| SCHEMBL5212645 | 0.74 | HPGD (0.68) | KMT2AMEN1HPGDALDH1A1UBE2T | |
| SCHEMBL1248387 | 0.73 | MAPT (0.58) | KMT2AMEN1HPGDALDH1A1CYP1A2 | |
| SCHEMBL5201727 | 0.73 | HTT (0.78) | KMT2AMEN1HPGDALDH1A1CYP1A2 | |
| SCHEMBL27412092 | 0.73 | HPGD (0.59) | KMT2AMEN1HPGDALDH1A1CYP1A2 | |
| SCHEMBL20511910 | 0.73 | CYP1A2 (0.73) | KMT2AMEN1HPGDALDH1A1CYP1A2 | |
| SCHEMBL14266782 | 0.73 | UBE2T (0.59) | KMT2AMEN1HPGDALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709040-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | Sirenade Pharmaceuticals AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068458-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | SIRENADE PHARMACEUTICALS AG (DE) | 2005-07-28 | — | — | WO | disclosed |