SCHEMBL77032

SCHEMBL77032

NC(=O)Cc1nc2ccccc2s1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.68
MEN1 O00255 3/20 0.68
HPGD P15428 3/20 0.68
ALDH1A1 P00352 1/20 0.68
MAPT P10636 4/20 0.67
UBE2T Q9NPD8 1/20 0.61
ASIC3 Q9UHC3 1/20 0.61
KDM4E B2RXH2 2/20 0.58
GAA P10253 2/20 0.58
SMN1; SMN2 Q16637 5/20 0.56
ALOX15 P16050 2/20 0.56
HTT P42858 1/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2C19 P33261 1/20 0.56
RAB9A P51151 4/20 0.56
NPC1 O15118 4/20 0.56
TP53 P04637 1/20 0.56
TSHR P16473 1/20 0.56
CASP1 P29466 1/20 0.56
HSD17B10 Q99714 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3684279 0.84 MAPT (0.60) KMT2AMEN1HPGDALDH1A1MAPT
SCHEMBL1612659 0.84 SMN1; SMN2 (0.67) KMT2AMEN1HPGDALDH1A1MAPT
SCHEMBL5212645 0.83 HPGD (0.68) KMT2AMEN1HPGDALDH1A1MAPT
SCHEMBL5312416 0.83 MAPT (0.58) KMT2AMEN1HPGDALDH1A1MAPT
Bromide SCHEMBL3868424 0.83 SMN1; SMN2 (0.65) KMT2AMEN1HPGDALDH1A1MAPT
SCHEMBL1398257 0.83 MAPT (0.67) KMT2AMEN1HPGDALDH1A1MAPT
SCHEMBL1248387 0.83 MAPT (0.58) KMT2AMEN1HPGDALDH1A1MAPT
SCHEMBL11266911 0.83 MAPT (0.67) KMT2AMEN1HPGDALDH1A1MAPT
SCHEMBL7656563 0.83 MAPT (0.58) KMT2AMEN1HPGDALDH1A1MAPT
SCHEMBL5401256 0.83 MAPT (0.67) KMT2AMEN1HPGDALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 266 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2753604-B1 PDE10 MODULATORS HOFFMANN LA ROCHE (CH) 2015-08-19 EP claimed
US-8772510-B2 PDE10 modulators HOFFMANN-LA ROCHE INC. (US) 2014-07-08 US claimed
EP-2574607-A1 PDE10 modulators F. Hoffmann-La Roche AG (CH) 2013-04-03 EP claimed
WO-2013034506-A1 PDE10 MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-14 WO claimed
US-20130059833-A1 PDE10 MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2013-03-07 US claimed
EP-2393790-A1 DERIVATIVES OF 6-(6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS SANOFI (FR) 2011-12-14 EP claimed
WO-2010089506-A1 DERIVATIVES OF 6-(6-O-CYCLOALKYL OR 6-NH-CYCLOALKYL-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS SANOFI-AVENTIS (FR) 2010-08-12 WO claimed
EP-2183232-A2 PI3 KINASE MODULATORS AND METHODS OF USE Amgen, Inc (US) 2010-05-12 EP claimed
CN-100520574-C Silver halide photosensitive material FUJI PHOTO FILM CO LTD (JP) 2009-07-29 CN claimed
WO-2009081222-A1 SUBSTITUTED TRICYCLIC PYRIDINE OR PYRIMIDINE VANILLOID RECEPTOR LIGANDS GLENMARK PHARMACEUTICALS, S.A. (US) 2009-07-02 WO claimed
US-4698297-A INCLUDING A CHEMICALLY STABLE COMPOUND ABLE TO RELEASE A USEFUL CONTROLLABLE GROUP HAVING GOOD DIFFUSION; SHARPNESS FUJI PHOTO FILM CO., LTD. (JP) 1987-10-06 US claimed
EP-0208502-A2 Light-sensitive silver halide color photographic material KONICA CORPORATION (JP) 1987-01-14 EP claimed
US-4618571-A STORAGE-STABLE COUPLERS; CONTROLLED-RELEASABLE COMPOUNDS FUJI PHOTO FILM CO., LTD. (JP) 1986-10-21 US claimed
US-4565777-A Silver halide color photographic light-sensitive materials FUJI PHOTO FILM CO., LTD. (JP) 1986-01-21 US claimed
EP-0157146-A2 Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1985-10-09 EP claimed
US-4533625-A COLOR COUPLER COMPRISING HYDROXYNAPHTHYL-SULFONYL OR -SULFINYL COMPOUND FUJI PHOTO FILM CO., LTD. (JP) 1985-08-06 US claimed
US-4526861-A Heterocyclic ring contains imide or sulfonamide group FUJI PHOTO FILM CO., LTD. (JP) 1985-07-02 US claimed
US-4511649-A Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1985-04-16 US claimed
EP-0126433-A2 Silver halide color photographic light-sensitive material FUJI PHOTO FILM CO., LTD. (JP) 1984-11-28 EP claimed
US-4477563-A DEVELOPMENT INHIBITION RELEASING COUPLERS FUJI PHOTO FILM CO., LTD. (JP) 1984-10-16 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130059833-A1 PDE10 MODULATORS PDE10A, PDE5A, PDE2A KMT2A 2193/4885MEN1 2291/4885HPGD 1466/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.