Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | CASP1 | P29466 | 2/20 | 0.45 |
| ▸ | CASP7 | P55210 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NOTCH1 | P46531 | 5/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5815739 | 0.84 | TSHR (0.61) | HTTNCOA1NCOA3ALDH1A1KDM4E | |
| SCHEMBL6029208 | 0.83 | NPSR1 (0.62) | HTTNCOA1NCOA3ALDH1A1KDM4E | |
| SCHEMBL17198741 | 0.83 | ALDH1A1 (0.63) | HTTNCOA1NCOA3GSK3AGSK3B | |
| SCHEMBL6027946 | 0.81 | KDM4E (0.56) | HTTNCOA1NCOA3GSK3AGSK3B | |
| SCHEMBL6032037 | 0.79 | GSK3A (0.48) | HTTNCOA1NCOA3GSK3AGSK3B | |
| SCHEMBL5816033 | 0.79 | KDM4E (0.58) | HTTNCOA1NCOA3GSK3AGSK3B | |
| SCHEMBL6027812 | 0.78 | ALDH1A1 (0.64) | HTTNCOA1NCOA3GSK3AGSK3B | |
| SCHEMBL6027944 | 0.77 | NPSR1 (0.52) | HTTALDH1A1KDM4ENPSR1TSHR | |
| SCHEMBL8654526 | 0.73 | MAPT (0.40) | ALDH1A1KDM4ETSHRHSD17B10TP53 | |
| SCHEMBL6461742 | 0.73 | ALDH1A1 (0.68) | HTTNCOA1NCOA3GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663227-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | Synta Pharmaceuticals Corporation (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005025507-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | SYNTA PHAMACEUTICALS CORP. (US) | 2005-03-24 | — | — | WO | disclosed |