Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2676424 | 0.82 | KLK5 (0.57) | SMN1; SMN2ALDH1A1KLK5NPC1RAB9A | |
| SCHEMBL30444890 | 0.82 | KLK5 (0.57) | SMN1; SMN2ALDH1A1KLK5NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5008243 | 0.81 | KLK5 (0.56) | SMN1; SMN2ALDH1A1KLK5NPC1RAB9A | |
| SCHEMBL6990517 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1KLK5NPC1RAB9A | |
| SCHEMBL19982873 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL2729927 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1KLK5NPC1RAB9A | |
| SCHEMBL760729 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1KLK5NPC1RAB9A | |
| SCHEMBL7738315 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KLK5NPC1RAB9A | |
| SCHEMBL16488211 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2ALDH1A1KLK5NPC1RAB9A | |
| SCHEMBL3534177 | 0.75 | SMN1; SMN2 (0.56) | SMN1; SMN2ALDH1A1KLK5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709040-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | Sirenade Pharmaceuticals AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068458-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | SIRENADE PHARMACEUTICALS AG (DE) | 2005-07-28 | — | — | WO | disclosed |
| EP-1555264-A1 | Five-membered heterocyclic compounds as inhibitors of SRC family protein kinase. | Sireen AG (DE) | 2005-07-20 | — | — | EP | disclosed |