Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5810204 | 0.87 | NPSR1 (0.54) | GSK3BALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL5222526 | 0.85 | GSK3B (0.60) | GSK3BKMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6027051 | 0.84 | GSK3B (0.48) | GSK3BKMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL5815747 | 0.76 | NPSR1 (0.67) | GSK3BALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL5820269 | 0.75 | HTR1A (0.60) | GSK3BALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL5813926 | 0.75 | GSK3B (0.58) | GSK3BKMT2AALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3320698 | 0.74 | KDM4E (0.60) | GSK3BALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL5810980 | 0.74 | HTR1A (0.63) | GSK3BALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL6028346 | 0.74 | HTR1A (0.63) | GSK3BALDH1A1KDM4EHSD17B10GAA | |
| SCHEMBL5815722 | 0.74 | HTR1A (0.63) | GSK3BALDH1A1KDM4EHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663227-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | Synta Pharmaceuticals Corporation (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005025507-A2 | DIHYDROPYRIDINE COMPOUNDS FOR TREATING OR PREVENTING METABOLIC DISORDERS | SYNTA PHAMACEUTICALS CORP. (US) | 2005-03-24 | — | — | WO | disclosed |