Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | MET | P08581 | 1/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.59 |
| ▸ | PRKACA | P17612 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.59 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | GSK3A | P49840 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | CDK7 | P50613 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34472005 | 1.00 | AURKA (0.59) | AURKAJAK2ABL1NTRK1LCK | |
| SCHEMBL250112 | 0.84 | AURKA (0.63) | AURKAJAK2ABL1NTRK1LCK | |
| SCHEMBL4770511 | 0.82 | AURKA (0.61) | AURKAJAK2ABL1NTRK1LCK | |
| SCHEMBL30075113 | 0.82 | AURKA (0.61) | AURKAJAK2ABL1NTRK1LCK | |
| SCHEMBL31232794 | 0.81 | PIM1 (0.59) | AURKAJAK2ABL1NTRK1LCK | |
| SCHEMBL5469161 | 0.81 | PIM1 (0.59) | AURKAJAK2ABL1NTRK1LCK | |
| SCHEMBL29688264 | 0.81 | AURKA (0.59) | AURKAJAK2ABL1NTRK1LCK | |
| SCHEMBL7406207 | 0.81 | AURKA (0.59) | AURKAJAK2ABL1NTRK1LCK | |
| SCHEMBL828618 | 0.81 | AURKA (0.59) | AURKAJAK2ABL1NTRK1LCK | |
| SCHEMBL10608668 | 0.81 | AURKA (0.59) | AURKAJAK2ABL1NTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0517476-B1 | Benzimidazole derivatives, a method for producing the same, agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof | SUMITOMO CHEMICAL CO (JP) | 1997-10-08 | — | — | EP | claimed |
| EP-0517476-A2 | Benzimidazole derivatives, a method for producing the same, agricultural and horticultural fungicides containing the same as an active ingredient and intermediate compounds thereof | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1992-12-09 | — | — | EP | claimed |
| CN-106905241-B | 1, 2-disubstituted benzimidazole derivative and application thereof | 沈阳药科大学 | 2020-03-17 | — | — | CN | disclosed |
| CN-107118249-B | 18 beta-glycyrrhetinic acid derivative and application thereof | 沈阳药科大学 | 2019-12-20 | — | — | CN | disclosed |
| EP-1709040-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | Sirenade Pharmaceuticals AG (DE) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068458-A2 | FIVE-MEMBERED HETEROCYCLIC COMPOUNDS AS INHIBITORS OF SRC FAMILY PROTEIN KINASE | SIRENADE PHARMACEUTICALS AG (DE) | 2005-07-28 | — | — | WO | disclosed |
| US-5958950-A | CARDIOVASCULAR DISORDERS | WARNER-LAMBERT COMPANY (US) | 1999-09-28 | — | — | US | disclosed |
| WO-1997012615-A1 | BENZIMIDAZOLE DERIVATIVES AS 15-LO INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1997-04-10 | — | — | WO | disclosed |