Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | YES1 | P07947 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169605 | 0.88 | LMNA (0.38) | STK17BSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL6028819 | 0.87 | KIT (0.39) | PDE5AHPGDMAPK1 | |
| SCHEMBL6029743 | 0.80 | KMT2A (0.41) | SMN1; SMN2HTTHPGDMAPK1 | |
| SCHEMBL6029207 | 0.79 | MCHR1 (0.38) | — | |
| SCHEMBL6028621 | 0.78 | LMNA (0.38) | STK17BSMN1; SMN2LMNAHTTNPSR1 | |
| SCHEMBL6029331 | 0.76 | LMNA (0.40) | SMN1; SMN2LMNAHTTHPGD | |
| SCHEMBL6029140 | 0.76 | KIT (0.40) | LMNANPSR1PDE5AHPGDMAPK1 | |
| SCHEMBL6030077 | 0.75 | MEN1 (0.52) | STK17BAAK1ALOX15HPGDROCK2 | |
| SCHEMBL6029135 | 0.72 | KMT2A (0.35) | STK17BSMN1; SMN2AAK1HPGDROCK2 | |
| SCHEMBL6029136 | 0.70 | LMNA (0.47) | STK17BSMN1; SMN2LMNAAAK1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984643-B2 | 2,5-substituted pyrimidine derivatives-CCR-3 receptor antagonists | ROCHE PALO ALTO LLC (US) | 2006-01-10 | — | — | US | disclosed |
| EP-1521582-A1 | 2,5-SUBSTITUTED PYRIMIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-04-13 | — | — | EP | disclosed |
| WO-2004004731-A1 | 2, 5-SUBSTITUTED PYRIMIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS IX | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-15 | — | — | WO | disclosed |