SCHEMBL6030306

SCHEMBL6030306

COc1ccc(-c2ccc3c(c2)C(c2cccc(C#N)c2)=NCC(=O)N3C)cc1OC.COc1ccc(-c2ccc3c(c2)C(c2cccc(C(N)=O)c2)=NCC(=O)N3C)cc1OC

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE2A O00408 2/20 0.66
GABRA1 P14867 7/20 0.55
GABRA5 P31644 7/20 0.55
GABRA2 P47869 7/20 0.55
GABRG2 P18507 6/20 0.55
GABRB3 P28472 6/20 0.55
GABRA3 P34903 6/20 0.55
GABRB2 P47870 5/20 0.44
HDAC1 Q13547 4/20 0.42
HDAC6 Q9UBN7 3/20 0.42
HDAC3 O15379 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC7 Q8WUI4 1/20 0.42
HDAC2 Q92769 1/20 0.42
HDAC10 Q969S8 1/20 0.42
HDAC11 Q96DB2 1/20 0.42
HDAC8 Q9BY41 1/20 0.42
HDAC9 Q9UKV0 1/20 0.42
HDAC5 Q9UQL6 1/20 0.42
KIT P10721 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5034727 0.92 PDE2A (0.73) PDE2AGABRA1GABRA5GABRA2GABRG2
SCHEMBL5034629 0.92 GABRA1 (0.63) PDE2AGABRA1GABRA5GABRA2GABRG2
SCHEMBL6031484 0.86 PDE2A (0.76) PDE2AGABRA1GABRA5GABRA2GABRG2
SCHEMBL4708998 0.85 PDE2A (0.82) PDE2AGABRA1GABRA5GABRA2GABRG2
SCHEMBL4708597 0.85 PDE2A (0.85) PDE2AGABRA1GABRA5GABRA2GABRG2
SCHEMBL6029932 0.85 PDE2A (0.66) PDE2AGABRA1GABRA5GABRA2GABRG2
SCHEMBL6028959 0.85 PDE2A (0.68) PDE2AGABRA1GABRA5GABRA2GABRG2
SCHEMBL5037509 0.84 PDE2A (0.72) PDE2AGABRA1GABRA5GABRA2GABRG2
SCHEMBL5038985 0.84 PDE2A (0.74) PDE2AGABRA1GABRA5GABRA2GABRG2
SCHEMBL5044286 0.83 PDE2A (0.68) PDE2AGABRA1GABRA5GABRA2GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1697332-A1 BENZO'1,4 ! DIAZEPIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE PDE2 INHIBITORS, PREPARATION AND THERAPEUTIC USE THEREOF NEURO3D (FR) 2006-09-06 EP disclosed
WO-2005063723-A1 BENZO`1,4 ! DIAZEPIN-2-ONE DERIVATIVES AS PHOSPHODIESTERASE PDE2 INHIBITORS, PREPARATION AND THERAPEUTIC USE THEREOF NEURO3D (FR) 2005-07-14 WO disclosed