Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.60 |
| ▸ | KDR | P35968 | 9/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.60 |
| ▸ | FLT1 | P17948 | 3/20 | 0.60 |
| ▸ | FLT4 | P35916 | 3/20 | 0.60 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | MC3R | P41968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375772 | 1.00 | EGFR (0.60) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4375238 | 0.87 | EGFR (0.60) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4375247 | 0.87 | EGFR (0.60) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4378628 | 0.87 | KDR (0.70) | EGFRKDRFGFR1FLT1EPHA2 | |
| SCHEMBL4374222 | 0.86 | KDR (0.70) | EGFRKDRFGFR1FLT1EPHA2 | |
| SCHEMBL4373829 | 0.86 | EGFR (0.67) | EGFRKDRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL4373692 | 0.85 | EGFR (0.66) | EGFRKDRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL4373326 | 0.84 | EGFR (0.62) | EGFRKDRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL4373331 | 0.84 | EGFR (0.62) | EGFRKDRFGFR1FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL4373588 | 0.83 | RET (0.69) | EGFRKDRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492560-B2 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2013-07-23 | — | — | US | disclosed |
| US-20120197027-A1 | Quinazoline Derivatives as Angiogenesis Inhibitors | STOKES ELAINE S E (GB) | 2012-08-02 | — | — | US | disclosed |
| US-7074800-B1 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2006-07-11 | — | — | US | disclosed |
| US-20060004017-A1 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB | 2006-01-05 | — | — | US | disclosed |
| EP-1553097-A1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS AND INTERMEDIATES THEREFORE | AstraZeneca AB (SE) | 2005-07-13 | — | — | EP | disclosed |
| EP-1154774-B1 | QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120197027-A1 | Quinazoline Derivatives as Angiogenesis Inhibitors | VEGFA, FLT1, KDR | EGFR 500/4885KDR 3/4885FGFR1 159/4885 |
| US-20060004017-A1 | Quinazoline derivatives as angiogenesis inhibitors | FLT4, NOS3, FLT1 | EGFR 549/4885KDR 4/4885FGFR1 298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.