Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CBFB | Q13951 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17731701 | 0.79 | NPC1 (0.46) | NPC1RAB9APTGESTRPV1MEN1 | |
| SCHEMBL6031259 | 0.77 | NPC1 (0.47) | NPC1RAB9ARPS6KA3CBFBGAA | |
| SCHEMBL1192237 | 0.77 | NPC1 (0.50) | NPC1RAB9APDE2ARPS6KA3CBFB | |
| SCHEMBL26810956 | 0.73 | CACNA1H (0.41) | PTGESCACNA1GCACNA1HCACNA1C | |
| SCHEMBL1128497 | 0.71 | NPC1 (0.45) | NPC1RAB9ATRPV1RPS6KA3CBFB | |
| SCHEMBL7345385 | 0.71 | RAB9A (0.45) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL7919226 | 0.69 | PARP1 (0.45) | PTGESMEN1KMT2APOLB | |
| SCHEMBL7614256 | 0.68 | NOTUM (0.31) | — | |
| SCHEMBL2418541 | 0.68 | CACNA1H (0.60) | CACNA1GCACNA1HCACNA1C | |
| SCHEMBL30822920 | 0.68 | CACNA1H (0.60) | CACNA1GCACNA1HCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Pharmaceuticals Corporation (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004100881-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-11-25 | — | — | WO | disclosed |