Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | UTRN | P46939 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.40 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.40 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL916067 | 0.80 | MAPT (0.65) | NOTUMCASP3PGRUTRNRAB9A | |
| SCHEMBL6032491 | 0.80 | MAPT (0.59) | CASP3RAB9ANPC1PTPN2PTPN5 | |
| SCHEMBL9608573 | 0.79 | NOTUM (0.53) | NOTUMPGRUTRNRAB9ANPC1 | |
| SCHEMBL6032690 | 0.74 | MAPT (0.61) | NOTUMUTRNRAB9ANPC1PTPN2 | |
| SCHEMBL442096 | 0.71 | TOP2A (0.48) | NOTUMPGRUTRNPTPN2PTPN1 | |
| SCHEMBL1780464 | 0.69 | PSMB8 (0.63) | NOTUMCASP3PGRRAB9ANPC1 | |
| SCHEMBL26818750 | 0.69 | PTPN2 (0.63) | PGRUTRNRAB9ANPC1PTPN2 | |
| SCHEMBL10344443 | 0.68 | ELANE (0.66) | NOTUMRAB9ANPC1MAPTALDH1A1 | |
| SCHEMBL2244350 | 0.68 | NPC1 (0.65) | CASP3UTRNRAB9ANPC1PTPN2 | |
| SCHEMBL5228147 | 0.68 | ESR1 (0.60) | NOTUMUTRNRAB9APTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631295-A2 | USE OF FUSED HETEROCYCLIC COMPOUNDS AS SCCE INHIBITORS FOR THE TREATMENT OF SKIN CONDITIONS OR CANCER | Arexis AB (SE) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004108139-A2 | USE OF FUSED HETEROCYCLIC COMPOUNDS AS SCCE INHIBITORS FOR THE TREATMENT OF SKIN CONDITIONS OR CANCER | AREXIS AB (SE) | 2004-12-16 | — | — | WO | disclosed |