SCHEMBL10344443

SCHEMBL10344443

O=c1oc(-c2cccc(C(F)(F)F)c2)nc2ccccc12

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 3/20 0.66
KMT2A Q03164 8/20 0.61
ALDH1A1 P00352 6/20 0.61
HPGD P15428 4/20 0.61
F2 P00734 2/20 0.61
MEN1 O00255 7/20 0.60
C1R P00736 1/20 0.58
TP53 P04637 3/20 0.57
SMN1; SMN2 Q16637 2/20 0.57
F7 P08709 1/20 0.56
F3 P13726 1/20 0.56
MAPT P10636 2/20 0.56
LMNA P02545 1/20 0.56
MAPK10 P53779 1/20 0.56
NPC1 O15118 4/20 0.56
RAB9A P51151 3/20 0.56
CYP1A2 P05177 2/20 0.56
CYP3A4 P08684 2/20 0.56
CYP2C19 P33261 2/20 0.56
CYP2C9 P11712 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5385451 0.88 HPN (0.52) ELANEKMT2AALDH1A1HPGDF2
SCHEMBL10741223 0.86 HPN (0.61) ELANEKMT2AALDH1A1HPGDF2
SCHEMBL272872 0.85 ELANE (0.83) ELANEKMT2AALDH1A1HPGDF2
SCHEMBL14273715 0.85 KDM4E (0.58) ELANEKMT2AALDH1A1HPGDF2
SCHEMBL11817024 0.85 ELANE (0.71) ELANEKMT2AALDH1A1HPGDF2
SCHEMBL5385483 0.84 F7 (0.49) ELANEKMT2AALDH1A1HPGDF2
SCHEMBL3452610 0.83 ELANE (0.60) ELANEKMT2AALDH1A1HPGDF2
SCHEMBL8493130 0.83 ELANE (0.67) ELANEKMT2AALDH1A1HPGDF2
SCHEMBL5371857 0.82 MAPT (0.64) KMT2AALDH1A1HPGDF2C1R
SCHEMBL5921381 0.82 ELANE (0.71) ELANEKMT2AALDH1A1HPGDF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-3970652-A Selectively herbicidal 2-substituted-4H-3,1-benzoxazin-4-ones GULF RESEARCH & DEVELOPMENT COMPANY (US) 1976-07-20 US claimed
EP-3628374-B1 BCL-3 INHIBITORS UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) 2023-08-30 EP disclosed
EP-3628374-B1 BCL-3 INHIBITORS UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) 2023-08-30 EP disclosed
EP-3628374-A2 BCL-3 INHIBITORS University College Cardiff Consultants Limited (GB) 2020-04-01 EP disclosed
EP-3628374-A2 BCL-3 INHIBITORS University College Cardiff Consultants Limited (GB) 2020-04-01 EP disclosed
US-20190248756-A1 BCL-3 INHIBITORS UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) 2019-08-15 US disclosed
US-20190248756-A1 BCL-3 INHIBITORS UNIV COLLEGE CARDIFF CONSULTANTS LTD (GB) 2019-08-15 US disclosed
US-10273218-B2 BCL-3 inhibitors UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2019-04-30 US disclosed
US-10273218-B2 BCL-3 inhibitors UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2019-04-30 US disclosed
US-20170267653-A1 BCL-3 INHIBITORS UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2017-09-21 US disclosed
EP-0067382-A2 N-cyclohexyl-chloroacetamides, their preparation and their use in combating undesired plant growth BASF Aktiengesellschaft (DE) 1982-12-22 EP disclosed
US-4363651-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1982-12-14 US disclosed
EP-0053698-A1 5-Amino-1-phenylpyrazole-4-carboxylic acids, process for their preparation, herbicides containing them and their use as herbicides BASF Aktiengesellschaft (DE) 1982-06-16 EP disclosed
EP-0053678-A1 5-Amino-1-phenyl-4-cyano pyrazoles, herbicides containing them, process for their preparation and their use as herbicides BASF Aktiengesellschaft (DE) 1982-06-16 EP disclosed
EP-0049398-A1 4H-3,1-Benzoxazin derivatives, process for their preparation and their use as herbicides BASF Aktiengesellschaft (DE) 1982-04-14 EP disclosed
US-4321371-A Substituted N-benzoylanthranilic acid derivatives and their anhydro compounds BASF AKTIENGESELLSCHAFT (DE) 1982-03-23 US disclosed
EP-0032242-A1 4H-3,1-benzoxazine derivatives, process for their preparation and their use in inhibiting the growth of unwanted plants BASF Aktiengesellschaft (DE) 1981-07-22 EP disclosed
EP-0024669-A1 Substituted N-benzoylanthranilic acid derivatives and their anhydro derivatives, process for their preparation, their use as herbicides and compositions therefor BASF Aktiengesellschaft (DE) 1981-03-11 EP disclosed
US-3970652-A Selectively herbicidal 2-substituted-4H-3,1-benzoxazin-4-ones GULF RESEARCH & DEVELOPMENT COMPANY (US) 1976-07-20 US disclosed
US-3970652-A Selectively herbicidal 2-substituted-4H-3,1-benzoxazin-4-ones GULF RESEARCH & DEVELOPMENT COMPANY (US) 1976-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190248756-A1 BCL-3 INHIBITORS BCL3, BCL2, BCL2L13 ELANE 4060/4885KMT2A 3099/4885ALDH1A1 2635/4885
US-10273218-B2 BCL-3 inhibitors BCL3, BCL2, BCL2L13 ELANE 3860/4885KMT2A 2931/4885ALDH1A1 2830/4885
US-20170267653-A1 BCL-3 INHIBITORS BCL3, BCL2, BCL2L13 ELANE 3860/4885KMT2A 2931/4885ALDH1A1 2830/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.