Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 12/20 | 0.64 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.49 |
| ▸ | KCNK4 | Q9NYG8 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CSGALNACT1 | Q8TDX6 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748124 | 1.00 | DGAT1 (0.64) | DGAT1KCNK2KCNK4NPC1RAB9A | |
| SCHEMBL1748125 | 1.00 | DGAT1 (0.64) | DGAT1KCNK2KCNK4NPC1RAB9A | |
| SCHEMBL1748123 | 1.00 | DGAT1 (0.64) | DGAT1KCNK2KCNK4NPC1RAB9A | |
| SCHEMBL2308884 | 0.89 | DGAT1 (0.60) | DGAT1CSGALNACT1LCK | |
| SCHEMBL2314966 | 0.89 | DGAT1 (0.60) | DGAT1CSGALNACT1LCK | |
| SCHEMBL2308048 | 0.89 | DGAT1 (0.60) | DGAT1CSGALNACT1LCK | |
| SCHEMBL2308770 | 0.89 | DGAT1 (0.64) | DGAT1NPC1RAB9ACSGALNACT1DYRK1A | |
| SCHEMBL12430212 | 0.89 | DGAT1 (0.80) | DGAT1NPC1RAB9ACSGALNACT1KDM4E | |
| SCHEMBL2306708 | 0.89 | DGAT1 (0.64) | DGAT1NPC1RAB9ACSGALNACT1DYRK1A | |
| SCHEMBL2310427 | 0.89 | DGAT1 (0.80) | DGAT1NPC1RAB9ACSGALNACT1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Pharmaceuticals Corporation (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004100881-A2 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-11-25 | — | — | WO | disclosed |