Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 18/20 | 0.56 |
| ▸ | ITGAV | P06756 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 6/20 | 0.43 |
| ▸ | F10 | P00742 | 4/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6031936 | 0.93 | ITGB3 (0.46) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL3267022 | 0.93 | ITGB3 (0.57) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7238070 | 0.91 | ITGB3 (0.54) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7229085 | 0.90 | ITGB3 (0.54) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7228211 | 0.90 | ITGB3 (0.54) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL3267949 | 0.88 | ITGB3 (0.51) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7236076 | 0.87 | ITGB3 (0.50) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL3266803 | 0.86 | GRM2 (0.52) | ITGB3ITGA2BGRM2PRSS1PRSS2 | |
| SCHEMBL7238569 | 0.84 | ITGB3 (0.52) | ITGB3ITGA2BITGAVCHRM2SLC6A4 | |
| SCHEMBL7229618 | 0.81 | GRM2 (0.50) | ITGB3ITGA2BGRM2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613268-A2 | METHODS FOR INHIBITION OF ANGIOGENESIS | The Scripps Research Institute (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004087057-A2 | METHODS FOR INHIBITION OF ANGIOGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-1997006791-A9 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF αvβ5 MEDIATED ANGIOGENESIS | — | 1997-04-03 | — | — | WO | disclosed |