Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.61 |
| ▸ | HPGD | P15428 | 7/20 | 0.61 |
| ▸ | TSHR | P16473 | 5/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.61 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrene SCHEMBL15110211 | 0.92 | ALDH1A1 (0.65) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 | |
| Pyrene SCHEMBL21599111 | 0.88 | ALDH1A1 (0.69) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 | |
| Pyrene SCHEMBL27945310 | 0.86 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 | |
| Pyrene SCHEMBL27931631 | 0.86 | ALDH1A1 (0.58) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 | |
| Pyrene SCHEMBL17023864 | 0.85 | KMT2A (0.52) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 | |
| Acetic Acid SCHEMBL27954037 | 0.85 | FFAR3 (0.47) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 | |
| Acetic Acid SCHEMBL27656922 | 0.85 | FFAR3 (0.47) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 | |
| Acetic Acid SCHEMBL29538855 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 | |
| Acetic Acid SCHEMBL28706282 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 | |
| Acetic Acid SCHEMBL28736368 | 0.84 | ALDH1A1 (0.50) | ALDH1A1HSD17B10HPGDTSHRCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113889577-B | Flexible field effect sensor and method for preparing same based on ultraviolet lithography | 中国农业科学院北京畜牧兽医研究所 | 2022-09-23 | — | — | CN | claimed |
| CN-113889577-A | Flexible field effect sensor and method for preparing same based on ultraviolet lithography | 中国农业科学院北京畜牧兽医研究所 | 2022-01-04 | — | — | CN | claimed |
| CN-108148001-A | Aryl imidazoles, preparation method and its dark blue photoelectricity electroluminescence device of hexyl substitution-fluorenes modification | 广东工业大学 | 2018-06-12 | — | — | CN | claimed |
| CN-106146829-B | A kind of polymer containing two or more pyrenyl groups and its production and use | 烟台大学 | 2018-01-30 | — | — | CN | claimed |
| CN-106146829-A | A kind of polymer containing two or more pyrenyl groups and its production and use | 烟台大学 | 2016-11-23 | — | — | CN | claimed |
| US-8778501-B2 | Fluorescent polymers for oxygen sensing | HONEYWELL INTERNATIONAL INC. (US) | 2014-07-15 | — | — | US | claimed |
| CN-103450714-A | Conductive graphite flake and preparation method thereof | TORAY ADVANCED MATERIALS RES LAB CHINA CO LTD | 2013-12-18 | — | — | CN | claimed |
| EP-2461155-B1 | Fluorescent polymers for oxygen sensing | HONEYWELL INT INC (US) | 2012-10-17 | — | — | EP | claimed |
| US-20120141807-A1 | FLUORESCENT POLYMERS FOR OXYGEN SENSING | HONEYWELL INTERNATIONAL INC. (US) | 2012-06-07 | — | — | US | claimed |
| EP-2461155-A1 | Fluorescent polymers for oxygen sensing | Honeywell International Inc. (US) | 2012-06-06 | — | — | EP | claimed |
| CN-119346074-A | Pyrenyl beta-cyclodextrin magnetic graphene oxide gel, preparation method thereof and application thereof in food safety detection | 中国检验检疫科学研究院 | 2025-01-24 | — | — | CN | disclosed |
| US-20230273193-A1 | SENSOR DEVICE, REAGENT FOR MODIFYING SURFACE OF SENSOR ELEMENT, METHOD OF MODIFYING SURFACE OF SENSOR ELEMENT AND METHOD OF MANUFACTURING SENSOR DEVICE | KABUSHIKI KAISHA TOSHIBA (JP) | 2023-08-31 | — | — | US | disclosed |
| CN-109270130-B | Systems and methods for analyte sensing in a physiological gas sample | 明尼苏达大学董事会 | 2023-08-29 | — | — | CN | disclosed |
| CN-116272697-A | Preparation method of hydrophobic molecular water-phase dispersion liquid | 上海慧翌新材料科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-113501860-B | Assembled nano liquid metal particles and preparation method and application thereof | 国家纳米科学中心 | 2023-06-16 | — | — | CN | disclosed |
| CN-1724597-A | Phase change inks | XEROX CORP (US) | 2006-01-25 | — | — | CN | disclosed |
| CN-1479870-A | Optical detection of glucose using boronic acid adducts | ���������Ǵ�ѧ���»� | 2004-03-03 | — | — | CN | disclosed |
| CN-1381713-A | Sensor for investigating metallorganic compound | DINASOERASTOUMIS S A (ES) | 2002-11-27 | — | — | CN | disclosed |
| CN-1301264-A | Pyrrolidine-3-carboxylic acid derivatives and their use as endothelin antagonists | ABBOTT LAB (US) | 2001-06-27 | — | — | CN | disclosed |
| US-5466578-A | Cationic surfactants and labels of fluorescent compounds containing pyrene, naphthalene or anthracene with phosphate groups | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 1995-11-14 | — | — | US | disclosed |