SCHEMBL6033073

SCHEMBL6033073

OCCC(OCCc1ccccc1)c1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.45
SLC6A2 P23975 5/20 0.40
SLC6A4 P31645 5/20 0.40
SLC6A3 Q01959 5/20 0.40
ACP3 P15309 1/20 0.40
SIGMAR1 Q99720 3/20 0.39
KCNH2 Q12809 3/20 0.39
TRPA1 O75762 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
CYP2D6 P10635 2/20 0.38
TP53 P04637 1/20 0.38
CYP1A2 P05177 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C9 P11712 1/20 0.38
ALOX15 P16050 1/20 0.38
TSHR P16473 1/20 0.38
NFKB1 P19838 1/20 0.38
MAPK1 P28482 1/20 0.38
CYP2C19 P33261 1/20 0.38
THPO P40225 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27948884 0.90 SLC6A2 (0.44) TDP1SLC6A2SLC6A4SLC6A3SIGMAR1
SCHEMBL27857107 0.86 GSR (0.46) TDP1SLC6A2SLC6A4SLC6A3ACP3
SCHEMBL19173724 0.82 TRPA1 (0.41) SLC6A2SLC6A4SLC6A3KCNH2TRPA1
SCHEMBL27568690 0.82 IDO1 (0.43) TDP1SLC6A2SLC6A4SLC6A3SIGMAR1
SCHEMBL7090878 0.80 TRPA1 (0.44) TDP1SLC6A2SLC6A4SLC6A3KCNH2
SCHEMBL8370117 0.79 TDP1 (0.48) TDP1TSHRRAB9AIDO1LMNA
SCHEMBL28130090 0.79 SLC6A2 (0.42) SLC6A2SLC6A4SLC6A3SIGMAR1KCNH2
SCHEMBL19511375 0.78 TRPA1 (0.41) TDP1TRPA1SMN1; SMN2TSHRRAB9A
SCHEMBL2377675 0.77 CHRNA7 (0.41) TDP1SIGMAR1SMN1; SMN2
SCHEMBL7960668 0.77 TRPA1 (0.46) SLC6A4TRPA1LMNAGSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1666473-A1 CARBOXYLIC ACID COMPOUNDS AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 2006-06-07 EP disclosed
US-5650410-A ANTIINFLAMMATORY AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-07-22 US disclosed