Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.48 |
| ▸ | CDC7 | O00311 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
| ▸ | PAK4 | O96013 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.48 |
| ▸ | CDK8 | P49336 | 2/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | PRKX | P51817 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | MELK | Q14680 | 2/20 | 0.48 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2728843 | 0.89 | ROCK2 (0.62) | ROCK2NPC1RAB9A | |
| SCHEMBL2727161 | 0.88 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL6033381 | 0.88 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL2727159 | 0.88 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL2725363 | 0.87 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL2725360 | 0.87 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL2727210 | 0.86 | ROCK2 (0.63) | ROCK2 | |
| SCHEMBL2727209 | 0.86 | ROCK2 (0.63) | ROCK2 | |
| SCHEMBL2729740 | 0.85 | ROCK2 (0.55) | ROCK2CDC7DAPK3PAK4CDK2 | |
| SCHEMBL2729742 | 0.85 | ROCK2 (0.57) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054367-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-04-26 | — | — | WO | disclosed |