SCHEMBL6033382

SCHEMBL6033382

CCOC(=O)CSc1nc2scc(-c3cccc(F)c3)c2c(=O)n1-c1cccc(F)c1

nearest known ligand 0.73

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 19/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6034271 0.94 TGM2 (0.78) TGM2
SCHEMBL6034363 0.91 TGM2 (0.78) TGM2
SCHEMBL6033427 0.90 TGM2 (0.74) TGM2
SCHEMBL6033367 0.89 TGM2 (0.74) TGM2
SCHEMBL6034116 0.88 TGM2 (0.78) TGM2
SCHEMBL6033420 0.87 TGM2 (0.70) TGM2
SCHEMBL6034031 0.86 TGM2 (0.75) TGM2
SCHEMBL6034168 0.86 TGM2 (0.72) TGM2
SCHEMBL6034163 0.86 TGM2 (0.72) TGM2
SCHEMBL6033346 0.85 TGM2 (0.65) TGM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006060702-A1 SUBSTITUED 3,4-DIHYDROTHIENO [2,3-D] PYRMIDINES AS TISSUE TRANSGLUTAMINASE INHIBITORS THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2006-06-08 WO disclosed