Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 14/20 | 0.67 |
| ▸ | KDR | P35968 | 10/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.49 |
| ▸ | TPX2 | Q9ULW0 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | FES | P07332 | 1/20 | 0.47 |
| ▸ | LYN | P07948 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6033588 | 0.90 | TEK (0.67) | TEKKDRSCN9AAURKAABL1 | |
| SCHEMBL1265673 | 0.86 | TEK (0.66) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1265206 | 0.86 | TEK (0.89) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1264513 | 0.84 | TEK (0.67) | TEKKDRAURKBSCN9AAURKA | |
| SCHEMBL1264508 | 0.82 | TEK (0.72) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL2293527 | 0.81 | TEK (0.72) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1264957 | 0.81 | TEK (0.99) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL2298956 | 0.80 | TEK (1.00) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL5259637 | 0.80 | TEK (0.72) | TEKKDRAURKBAURKATPX2 | |
| SCHEMBL1265904 | 0.80 | TEK (0.63) | TEKKDRAURKBAURKATPX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060009453-A1 | Protein kinase modulators and method of use | AMGEN INC. | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009453-A1 | Protein kinase modulators and method of use | PHKG1, PRKCH, BMP2K | TEK 215/4885KDR 58/4885AURKB 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.