Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069287 | 1.00 | ALDH1A1 (0.44) | ALDH1A1GAASMN1; SMN2KDM4EHPGD | |
| SCHEMBL3503589 | 1.00 | ALDH1A1 (0.44) | ALDH1A1GAASMN1; SMN2KDM4EHPGD | |
| SCHEMBL4069284 | 1.00 | ALDH1A1 (0.44) | ALDH1A1GAASMN1; SMN2KDM4EHPGD | |
| SCHEMBL19815819 | 0.84 | ALDH1A1 (0.42) | ALDH1A1GAAKDM4EHPGDHSD17B10 | |
| SCHEMBL11617483 | 0.83 | KDM4E (0.44) | ALDH1A1GAAKDM4EHPGDHSD17B10 | |
| SCHEMBL23123467 | 0.80 | KMT2A (0.41) | ALDH1A1GAASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL23122907 | 0.80 | KMT2A (0.41) | ALDH1A1GAASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL2771146 | 0.79 | KMT2A (0.56) | ALDH1A1GAASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL3090131 | 0.79 | KMT2A (0.56) | ALDH1A1GAASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL3070877 | 0.79 | KMT2A (0.56) | ALDH1A1GAASMN1; SMN2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692085-A2 | INHIBITION OF FGFR3 AND TREATMENT OF MULTIPLE MYELOMA | Chiron Corporation (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005047244-A2 | INHIBITION OF FGFR3 AND TREATMENT OF MULTIPLE MYELOMA | CHIRON CORPORATION (US) | 2005-05-26 | — | — | WO | disclosed |