Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6422777 | 0.89 | PTGS1 (0.50) | PTGS1SMN1; SMN2LTA4HALOX5ALDH1A1 | |
| SCHEMBL6034137 | 0.87 | FNTA (0.44) | PTGS1LTA4HALOX5 | |
| SCHEMBL6420384 | 0.83 | FNTA (0.47) | PTGS1SMN1; SMN2LTA4HFFAR1KMT2A | |
| SCHEMBL12905150 | 0.80 | ACACB (0.46) | HTTTDP1L3MBTL1PTGS1CYP2C9 | |
| SCHEMBL6927080 | 0.80 | KMT2A (0.59) | HTTTDP1L3MBTL1PTGS1SMN1; SMN2 | |
| SCHEMBL7086705 | 0.80 | KMT2A (0.59) | HTTTDP1L3MBTL1PTGS1SMN1; SMN2 | |
| SCHEMBL7090778 | 0.80 | KMT2A (0.59) | HTTTDP1L3MBTL1PTGS1SMN1; SMN2 | |
| SCHEMBL6419474 | 0.80 | FDFT1 (0.45) | HTTL3MBTL1SMN1; SMN2LTA4HALDH1A1 | |
| Hydrochloric Acid SCHEMBL20546770 | 0.79 | KMT2A (0.57) | HTTTDP1L3MBTL1PTGS1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7091447 | 0.79 | KMT2A (0.57) | HTTTDP1L3MBTL1PTGS1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1882375-A | treatment of amyloid-and epileptogenesis-related diseases | NEUROCHEM INTERNAT LTD (CH) | 2006-12-20 | — | — | CN | disclosed |
| EP-1635909-A2 | TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES | Neurochem (International) Limited (CH) | 2006-03-22 | — | — | EP | disclosed |
| US-20050038000-A1 | Methods and compositions for the treatment of amyloid-and epileptogenesis-associated diseases | BELLUS HEALTH (INTERNATIONAL) LIMITED (CH) | 2005-02-17 | — | — | US | disclosed |
| WO-2005000406-A2 | TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038000-A1 | Methods and compositions for the treatment of amyloid-and epileptogenesis-associated diseases | APP, PSEN1, PSEN2 | HTT 91/4885TDP1 1574/4885L3MBTL1 4161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.