Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10773328 | 0.90 | POLB (0.39) | POLBIMPDH2ATMNPC1RAB9A | |
| SCHEMBL21428120 | 0.78 | ATM (0.37) | POLBIMPDH2ATMNPC1RAB9A | |
| SCHEMBL1526199 | 0.78 | POLB (0.43) | POLBATMNPC1RAB9ACNR1 | |
| SCHEMBL4696449 | 0.76 | POLB (0.35) | POLBATMNPC1RAB9ACNR1 | |
| SCHEMBL7611640 | 0.74 | TGFBR1 (0.39) | POLBATMNPC1RAB9ACNR1 | |
| SCHEMBL27077599 | 0.74 | POLB (0.47) | POLBATMNPC1RAB9ACNR1 | |
| SCHEMBL16188979 | 0.73 | POLB (0.33) | POLBATMNPC1RAB9ACNR1 | |
| SCHEMBL2857868 | 0.72 | — | — | |
| SCHEMBL2490315 | 0.72 | — | — | |
| SCHEMBL16176331 | 0.71 | POLB (0.33) | POLBATMNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680429-A1 | THIENO-PYRIDINONE DERIVATIVES AS KINASE INHIBITORS | Celltech R & D Limited (GB) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005042540-A1 | THIENO-PYRIDINONE DERIVATIVES AS KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2005-05-12 | — | — | WO | disclosed |