Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 4/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ODC1 | P11926 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL9857117 | 0.93 | DNM1 (0.33) | DNM1MEN1KMT2AALDH1A1TSHR | |
| Ethylenediamine SCHEMBL2099890 | 0.90 | KDM4E (0.32) | — | |
| Propylamine SCHEMBL3969891 | 0.89 | DNM1 (0.35) | DNM1MEN1KMT2AALDH1A1TSHR | |
| Propylamine SCHEMBL20678533 | 0.86 | DNM1 (0.33) | DNM1MEN1KMT2AALDH1A1TSHR | |
| Propylamine SCHEMBL28311052 | 0.86 | DNM1 (0.38) | DNM1MEN1KMT2AALDH1A1TSHR | |
| Ethylamine SCHEMBL28061240 | 0.85 | DNM1 (0.30) | DNM1MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL19551357 | 0.83 | — | — | |
| SCHEMBL21550300 | 0.83 | — | — | |
| SCHEMBL28319618 | 0.81 | — | — | |
| Butylamine SCHEMBL5348470 | 0.81 | DNM1 (0.50) | DNM1MEN1KMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7019037-B2 | Monolayer coated aerogels and method of making | BATTELLE MEMORIAL INSTITUTE (US) | 2006-03-28 | — | — | US | disclosed |
| US-20030092778-A1 | Monolayer coated aerogels and method of making | U.S. DEPARTMENT OF ENERGY | 2003-05-15 | — | — | US | disclosed |
| WO-2003037793-A2 | MONOLAYER COATED AEROGELS AND METHOD OF MAKING | BATTELLE MEMORIAL INSTITUTE (US) | 2003-05-08 | — | — | WO | disclosed |
| EP-0275541-A1 | Less rigid, low or free boron glass fibers treated with amine-containing silanes | PPG INDUSTRIES, INC. (US) | 1988-07-27 | — | — | EP | disclosed |
| US-4027071-A | POLYVINYL ACETATE FILM, FATTY ACID AMIDE LUBRICANT, DIAMINO-TRIALKYLOXYSILANE AND METHACRYLATO CHROMIC HALIDE | PPG INDUSTRIES, INC. (US) | 1977-05-31 | — | — | US | disclosed |
| US-3933711-A | Forming size of aqueous polyvinylacetate | PPG INDUSTRIES, INC. (US) | 1976-01-20 | — | — | US | disclosed |