Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Ciaftalan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ciaftalan SCHEMBL8909820 | 0.98 | MEN1 (0.43) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL14690839 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL6037601 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL4415382 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL4970464 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL11063880 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL38592 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL3246108 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL31088182 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB | |
| Ciaftalan SCHEMBL6855604 | 0.98 | MEN1 (0.45) | MEN1KMT2ATDP1RECQLTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040058253-A1 | Mirror for exposure system, reflection mask for exposure system, exposure system and pattern formation method | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD | 2004-03-25 | — | — | US | claimed |
| CN-110379915-B | Halogenated metal phthalocyanine complex thermoelectric material and preparation method thereof | 中国科学院上海硅酸盐研究所 | 2021-02-12 | — | — | CN | disclosed |
| US-20060008711-A1 | Mirror for exposure system, reflection mask for exposure system, exposure system and pattern formation method | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. (JP) | 2006-01-12 | — | — | US | disclosed |
| US-20040058253-A1 | Mirror for exposure system, reflection mask for exposure system, exposure system and pattern formation method | MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD | 2004-03-25 | — | — | US | disclosed |